Structural and practical identifiability of contrast transport models for DCE-MRI
Fig 7
Study on the smoothing effect on parameter practical identifiability for the LTK model.
Top row: CA profile obtained from the GBM data in a Type I enhancement curve by smoothing the data using a moving average method with different values of the smoothing factor γ, i.e., γ = 0.05 (second column), γ = 0.1 (third column), and γ = 0.15 (fourth column). The original GBM data (first column) are the same used in the (RR) case. Bottom row: profile likelihood and confidence levels at 68%, 80%, and 95% for the parameter Ktrans obtained by repeating the study on Ktrans with the smoothed data illustrated in the top row.