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Structural and practical identifiability of contrast transport models for DCE-MRI

Fig 5

Leakage (λ) practical identifiability for LTK model and Type I enhancement curve.

Top row: profile likelihood and confidence levels at 68%, 80%, and 95% for the parameter Kλ in the (AA), (RA), and (RR) case for the Type I enhancement curve. Inset in the first subplot shows a zoom of the region around the best-fitted value (red marker). Bottom row: compensating profiles of the parameters K^trans, v_e, and v_p with respect to variation of λ around its best-fitted value. Variation of ±50% around the optimal value of λ are considered. Two colors are for two different y-axis: black curves refer the left y-axis and red curves to the right y-axis. Different line styles are used to distinguish curves referring to the same y-axis. For each curve, the name of the corresponding parameter is indicated above the line in the same color.

doi: https://doi.org/10.1371/journal.pcbi.1012106.g005