A mathematical model for the role of dopamine-D2 self-regulation in the production of ultradian rhythms
Fig 7
Phase-dependent effect of a transient excitatory pulse on the ultradian oscillation.
A: DAex behaviour in response to a single pulse input (Isens = 75, duration = 15 min) given at various phases. The black solid line represents the DAex trajectory without additional input. The dotted and solid coloured lines represent DAex trajectories during and after the pulse, with colours denoting the ultradian phase when the pulse is given. B: Phase response curve and amplitude response curve of DAex to a pulse input of various magnitude/duration combinations. The evoked phase shift and the percentage change of maximum-minimum DAex values within the immediate cycle are plotted against the timing of a centred pulse on the ultradian cycle.