A mathematical model for the role of dopamine-D2 self-regulation in the production of ultradian rhythms
Fig 2
Simulated output of the core DUSR model.
An ultradian rhythm (period = 4.0 h) for key output variables: extracellular dopamine (DAex), activated D2-autoreceptors (D2AR), dopamine transporter activity (TDA), and DAergic neuron firing rate (F). F is plotted as a ratio over the maximum firing rate Fmax. Vertical lines indicate the peak phases of DA; red circles on the plotted lines mark the peak phase of the respective variable. F of the release loop phase-leads D2AR and TDA of the removal loop.