Cooltools: Enabling high-resolution Hi-C analysis in Python
Fig 5
a. Diamond insulation is calculated as the sum in a sliding window (gray) across the genome, shown here for HFF MicroC data in a region of chr2 at 10kb resolution (chr2:10900000–11650000). b. The resulting insulation profile is shown in black. Local minima are indicated with dots. Positions of strong boundaries shown as orange dots, and filtered weak boundaries as blue dots. Two-sided gray arrow shows the boundary strength of the strong boundary at chr2:1146000–1147000, calculated relative to the maximum insulation achieved before a more prominent minima in either genomic direction. Here, strength is relative to the prominent minima at chr2:11130000–11140000, and maximum insulation is indicated with a dashed gray line.