Modeling the START transition in the budding yeast cell cycle
Fig 7
Simulation of non-phosphorylable mutants.
The simulations shown here track the cell size and key active SBF/MBF fractions, in specific non-phosphorylable START mutants, and the descriptions are as in Fig 4. (A) WHI5-12A (SBF-Whi5 complex phosphorylated on Swi6 and MBF are the primary active forms–SBFa3, MBFa; cells are ~WT size), (B) SWI6-SA4 (SBF activated by Bck2, SBF-Whi5 complex phosphorylated on Whi5, and MBF are the primary active forms–SBFa4, MBFa; cells are ~WT size), (C) WHI5-12A SWI6-SA4 (only very little of Bck2 activated MBF forms are present–MBFa; cells are larger than WT).