Modeling the START transition in the budding yeast cell cycle
Fig 6
Simulation of the timing of localization (export) of different monomers.
The cytoplasmic fraction of monomers Swi4, Swi6 and Whi5 are plotted against time. The bar at the bottom of the graph shows timing w.r.t. phases of the cell cycle. In the model, the onset of S and M phases correspond to DNA synthesis (ORI = 1) and spindle assembly checkpoint (SPN = 1), respectively. In compliance with experiments, Whi5 enters the cytoplasm (exits the nucleus) in late G1, followed by Swi6 in S-phase. Both Swi6 and Whi5 are cytoplasmic until mitotic exit. Swi4 is mostly nuclear at all times. Details are discussed in the main text.