StellarPath: Hierarchical-vertical multi-omics classifier synergizes stable markers and interpretable similarity networks for patient profiling
Fig 4
Molecules and pathways relevance.
(A) Scatter plot of the pathways represented by predictive OGD WT signature PSNs. The X-axis indicates how much the OGD WT samples are cohesive in the PSN associated with a pathway. The Y-axis indicates how much the N WT samples are cohesive. The size of the dot indicates how many molecules are significantly deregulating a pathway. The color indicates if a pathway is associated with the OGD phenotype based on IPA. The best pathways are in the bottom right corner because of strong similarities between OGD WT samples and weak similarities between the N WT ones. (B) Scatter plot of the deregulated molecules belonging to the enriched pathways represented by predictive OGD WT signature PSNs. The X-axis indicates how much a molecule is stable in the OGD WT samples against the controls. The Y-axis indicates how much a molecule is deregulated between OGD WT versus N WT. The best molecules are in the top right part of the plot because they are the most deregulated and stable in OGD WT.