Evolution of phenotypic plasticity leads to tumor heterogeneity with implications for therapy
Fig 5
Genetic and phenotypic heterogeneity predict treatment success.
Shown is the time to recurrence of synthetic tumors versus the genetic entropy (A) and phenotypic entropy (B). Higher phenotypic entropy is associated with lower recurrence times, while higher genetic entropy is associated with higher recurrence time, corresponding to better prognosis. Black dashed lines are linear regressions.