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Convergence, sampling and total order estimator effects on parameter orthogonality in global sensitivity analysis

Fig 9

Total order Sobol indices S_T of the maximal left ventricular elastance for the 2-chamber model with continuous measurements.

Panels A—T show S_T of , for 3 continuous measurements—left ventricular pressure, systemic arterial pressure and the left ventricular volume (represented in blue, yellow and green curves, respectively), over a single cardiac cycle with differing estimators and sampling methodologies. Measurements are evaluated with N = 20, 000 samples, using B = 1000 bootstrapped samples to evaluate the uncertainty of the estimate. The bands represent 95% confidence intervals associated with specific indices displayed as solid curves.

doi: https://doi.org/10.1371/journal.pcbi.1011946.g009