Convergence, sampling and total order estimator effects on parameter orthogonality in global sensitivity analysis
Fig 7
Total order Sobol indices ST of the mitral valve resistance Rmv for the 1-chamber model with discrete measurements.
Panels A—T show ST of Rmv, for 3 discrete measurements: mean left ventricular pressure, maximum systemic arterial pressure and maximum left ventricular volume (represented in blue, yellow and green, respectively), evaluated at increasing sample sizes (N ∈ [2000, 40000] using B = 1000 bootstrapped samples), with differing estimators and sampling methodologies. The bands represent 95% confidence intervals associated with specific indices displayed as solid curves. The red solid vertical lines represent the point (N = 10, 000) at which the sample size is taken.