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Convergence, sampling and total order estimator effects on parameter orthogonality in global sensitivity analysis

Fig 6

Orthogonality distributions of input parameters for the 1-chamber model with continuous measurements—Histograms A-T show the distribution of orthogonality returned from examinations of the sensitivity vectors, calculated from continuous measurements.

Here, an orthogonality score of 1 represents total independence of input parameters, whereas 0 represents total dependence. Each individual diagram denotes a specific combination of sampling methodology and estimator type. The frequency of each histogram is normalised such that it is comparable between plots, i.e., the larger the frequency of a bin, the larger the number of orthogonality scores calculated from the original sensitivity vectors.

Fig 6

doi: https://doi.org/10.1371/journal.pcbi.1011946.g006