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Convergence, sampling and total order estimator effects on parameter orthogonality in global sensitivity analysis

Fig 5

Total order Sobol indices ST of the arterial compliance Csa for the 1-chamber model with continuous measurements.

Panels A—T show ST of Csa, for 3 continuous measurements—left ventricular pressure, systemic arterial pressure and the left ventricular volume (represented in blue, yellow and green curves, respectively), over a single cardiac cycle with differing estimators and sampling methodologies. Measurements are evaluated with N = 10, 000 samples, using B = 1000 bootstrapped samples to evaluate the uncertainty of the estimate. The bands represent 95% confidence intervals associated with specific indices displayed as solid curves.

Fig 5

doi: https://doi.org/10.1371/journal.pcbi.1011946.g005