Metabolic symbiosis between oxygenated and hypoxic tumour cells: An agent-based modelling study
Fig 10
MCT1 and GLUT1 inhibition with alternative and periodic drug administration.
Heatmaps depicting how MCT1 and GLUT1 inhibitors interfere with glycolysis, OXPHOS, and tumour growth when both drugs were given alternatively and periodically. Both MCT1i and GLUT1i concentrations were kept at same level, and it was maintained at 1, 10 and 100 of respective half-maximal inhibitory concentration (IC50) value. Inhibitor concentration was maintained at the boundary of the computational domain and varied periodically throughout the simulation time. The initial tumour consisted of 100 cells, with p53- status. Number of total cells, OXPHOS cell population and glycolytic cell population of p53- tumour after 30 days of growth are shown. The period “NA” represents the simulation with continuous supply of both drugs at half of the respective concentration.