Metabolic symbiosis between oxygenated and hypoxic tumour cells: An agent-based modelling study
Fig 7
Symbiosis-induced percentage change of glucose and oxygen in the tumour microenvironment.
(A-B). Percentage change of (A) glucose and (B) oxygen in the tumour microenvironment over time for tumour growth with p53wt and p53- status. Length and red lines are as described in Fig 6. The model was run with MCT1wt and MCT1- status. The percentage change of glucose and oxygen in the tumour microenvironment was calculated over time. The heat maps suggest that symbiosis increases glucose level while decreasing oxygen level at the tumour boundary. More supplementary results are shown in S8 Fig.