Metabolic symbiosis between oxygenated and hypoxic tumour cells: An agent-based modelling study
Fig 6
Distribution of tumour microenvironmental substances under wild type and mutated p53 status.
(A-D). Heat maps show spatial-temporal variation of microenvironmental (A) oxygen, (B) glucose, (C) lactate, and (D) pH levels for p53wt and p53- tumour growth (here, the Length is the cross section of the tumour microenvironment through the center of the tumour). Red lines show the development of tumour boundary over time. The results show that p53 loss of function could make the tumour microenvironment more acidic during the period of time (i.e., 25 days) considered here. This is mainly because the p53- tumour grows faster and therefore more waste products are accumulated inside the tumour making it more acidic.