Metabolic symbiosis between oxygenated and hypoxic tumour cells: An agent-based modelling study
Fig 5
Tumour growth under wild type and mutated p53 status.
Effect of p53 status on OXPHOS (shown as mitoATP), glycolysis (shown as glycoATP) and ATP production rate are shown. p53wt and p53- cells were grown in isolation. The starting number of cells was 100. (A, B). Growth of p53wt (A) and p53- (B) cells over time. The OXPHOS cell population is marginally dominant over glycolytic population regardless of the p53 status. (C). Evolution of OXPHOS/Glycolysis cell ratio with p53wt and p53- status. (D, E). Variation of OXPHOS (mitoATP) and glycolytic (mitoATP) ATP production rate of p53wt (D) and p53- (E) cells as tumour grows. The tumour cells with p53 knockout were found to grow faster than p53wt cells because they lacked p53 to suppress tumour growth.