Metabolic symbiosis between oxygenated and hypoxic tumour cells: An agent-based modelling study
Fig 4
Metabolic symbiosis simulations with network gene alterations: The gene enriched (+) and knockout (-) status were simulated by setting the respective node of the regulatory network to 1 and 0, respectively.
The gene wild type (WT) status was simulated without setting the respective node to either 0 or 1. Each gene was altered individually. (A). Percentage tumour growth increase due to symbiosis is shown for each gene enrichment status. (B). Percentage tumour growth increase due to symbiosis is shown for each gene knockout status. (C). Whether tumour growth is significantly different (p-value < 0.05) between symbiosis and non-symbiosis for each gene enrichment status is shown. (D). Whether tumour growth is significantly different (p-value < 0.05) between symbiosis and non-symbiosis for each gene knockout status is shown. Clusters of gene alterations can be identified, which enhance tumour growth due to symbiosis while some other gene alterations together with symbiosis adversely affect tumour growth (A, B). Colours indicate percentage growth increase by symbiosis (A, B) and p values (C, D). p values from 0 to 0.05 are shown in red to white colour scale and p values ≥ 0.05 are shown in grey colour.