Dissecting the roles of calcium cycling and its coupling with voltage in the genesis of early afterdepolarizations in cardiac myocyte models
Fig 5
EADs driven by oscillations caused by the Ca-ICa,L-Vm-Ca feedback loop.
A. Vm, [Ca]sub, ICa,L, and INCX versus time for a representative case [α(GKs) = 1.6 and α(PCa) = 8.2, square in Fig 2A]. The left vertical dashed line indicates the peak and the right one indicates the valley of [Ca]sub. B. Vm and [Ca]sub versus time when [Ca]sub is clamped at the lowest (red), middle (green), and highest (blue) levels during the plateau phase. C. Vm and [Ca]sub versus time when Vm is clamped at lowest (red) and highest (blue) levels in the plateau phase. D. [Ca]sub versus Vm from simulations using the Vm clamp protocol in which Vm is switched from -80 mV to different clamped levels. Black dots: INCX = 0. Red dots: ICa,L = 0. The inset is a schematic plot of the feedback loop.