Dissecting the roles of calcium cycling and its coupling with voltage in the genesis of early afterdepolarizations in cardiac myocyte models
Fig 3
EAD behaviors under S1S1 and S1S2 pacing protocols.
A. Phase diagram obtained with the S1S1 protocol. The parameter set is the same as Fig 2A. S1S1 interval = 3 s. The grey region is determined using the criterion of APD being greater than the S1S1 interval. The colored regions are different EAD regions classified by the same way as in Fig 2A. B. Phase diagram obtained with the S1S2 protocol. The EAD classification is done using the S2 beat. The S1S1 interval is 1 s and the S1S2 interval is 2 s. C. An example showing Vm and [Ca]sub versus time from the regime of Vm-driven EADs with the S1S1 protocol. α(GKs)=0.8 and α(PCa)=4.4. The traces in the right panels are those when [Ca]sub is clamped in the last pacing beat. D. An example showing Vm and [Ca]sub versus time from the regime of Vm-driven EADs with the S1S2 protocol. α(GKs)=0.8 and α(PCa)=4.6. The traces in the right panels are those when [Ca]sub is clamped in the S2 beat.