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Dissecting the roles of calcium cycling and its coupling with voltage in the genesis of early afterdepolarizations in cardiac myocyte models
Fig 2
EADs driven by Vm oscillations.
A. Phase diagram showing different EAD behaviors in the α(PCa) − α(GKs) plane for α(kmax) = 2, α(JCaslmyo) = 2.64, and 
. The grey and white regions represent repolarization failure and normal repolarization, respectively. Insets show two representative APs. Three types of EADs are observed, as colored dark yellow, green, and magenta. B. A representative AP and associated currents in the dark yellow region (i.e., EADs driven by Vm oscillations). The parameter set is α(GKs) = 1.16 and α(PCa) = 5.4, as marked by the black circle in A. The dashed vertical lines indicate the takeoff moments of the two EADs. The grey patch indicates the range of [Ca]sub clamped used in the [Ca]sub-clamp simulations. C. An example showing Vm and [Ca]sub versus time with [Ca]sub being clamped at the lowest (red) and highest (blue) levels.
doi: https://doi.org/10.1371/journal.pcbi.1011930.g002