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Decomposing bulk signals to reveal hidden information in processive enzyme reactions: A case study in mRNA translation

Fig 5

Decomposition of fluorescence signatures of mRNAs consisting of 26 identical codons with Tikhonov regularization.

a): For different values of α, the norm of the regularized solution is plotted versus the residual norm . The log-log plot shows the characteristic L-shaped curve. The optimal regularization parameter in terms of trade-off between regularization and perturbation error is α = 0.01 and is found by locating the corner of the curve. b): Input and fitted IFI vectors for three different regularization parameter values.

doi: https://doi.org/10.1371/journal.pcbi.1011918.g005