Circadian regulation of sinoatrial nodal cell pacemaking function: Dissecting the roles of autonomic control, body temperature, and local circadian rhythmicity
Fig 6
Illustrative trajectories in the parameter space of SANC flexibility, performance and robustness.
(A) Uphill trajectories show the transition from baseline (grey circle) to adult (CRBT + ANS + LCR; grey dot) model states. (B) Downhill trajectories demonstrate the transition from adult (grey dot) to aged model states (red dot).