Circadian regulation of sinoatrial nodal cell pacemaking function: Dissecting the roles of autonomic control, body temperature, and local circadian rhythmicity
Fig 5
Distinct mechanisms underlying circadian patterns of SANC FR in adult and aged mice.
(A-B) Relative contributions to SANC flexibility and performance are quantified by selective inhibition of each module in the adult (A) and aged (B) models. (C) Relative contributions to aging-dependent reduction in SANC flexibility and performance are quantified by selective inhibition of each aging-dependent change in the aged model (red box).