Circadian regulation of sinoatrial nodal cell pacemaking function: Dissecting the roles of autonomic control, body temperature, and local circadian rhythmicity
Fig 3
The alliance of ANS, CRBT and LCR is essential to achieve circadian flexibility and performance while preserving robustness in SANC automaticity.
(A) CO-MO parameter space maps color-coded by FR in BPM at ZT6 and ZT18 under control conditions in adult model. (B) Steady-state SANC membrane potential oscillations using parameter settings sampled from panel (A; labeled 1 to 6). (C-G) CO-MO parameter space maps at ZT6 and ZT18 under (CRBT-/-) (C), (CRBT-/-; LCR-/-) (D), (CRBT-/-; ANS-/-) (E), (CRBT-/-; SNA-/-) (F), and (CRBT-/-; PNA-/-) (G) conditions. (H-J) Quantification of SANC flexibility (H), performance (I), and robustness (J) under various conditions. (K) Normalized changes in SANC flexibility, performance, and robustness compared to the control conditions in adult model.