It is theoretically possible to avoid misfolding into non-covalent lasso entanglements using small molecule drugs
Fig 4
Two parallel paths to forming an entanglement involving a single threading event.
Orange circles represent the two residues forming the native contact that closes the loop. The loop and threading segment are shown in red and blue, respectively. A table is presented at the bottom showing the probabilities of both paths utilized by the native and misfolding pathways, respectively. The 95% confidence intervals were estimated by bootstrapping and are presented in the bracket for the probability value less than 100%.