Cortical cell assemblies and their underlying connectivity: An in silico study
Fig 5
Synapse clustering coefficient determines cell assembly membership.
A: Probability of membership in exemplary early (first), middle (second), and late (third) assemblies against synapse clustering coefficient (SCC, see Methods) with respect to all assemblies. Fourth: nI (normalized mutual information, see Methods) of SCC and assembly membership. B: Combined effect of SCC and indegree (as in Fig 4d). First: Probability of membership in an exemplary early assembly, against 0-indegree with respect to the same assembly, grouped by SCC significance (see Methods). Second: Joint distribution of SCC and 0-indegree. Third: nI of SCC and assembly membership conditioned on 0-indegree. Fourth: Relation of nI and conditional nI grouped by postsynaptic early, middle, and late assemblies (i.e., rows of the matrices in A fourth, and B third). C: Simulation results for 10 selected neurons per assembly (with the highest 0-indegree and significant clustering; red arrow in B left) with modified physiological conditions. Left: correlation of spike times with the assembly. Right: Single cell firing rates.