StressME: Unified computing framework of Escherichia coli metabolism, gene expression, and stress responses
Fig 5
Computing alternative optimal solutions from StressME by Flux variability analysis (FVA).
FVA for the heat-evolved strain (A)-(D): (A) glucose uptake rates (GUR), (B) oxygen uptake rates (OUR), (C) CO2 production/uptake rates (CO2) and (D) acetate production rates (APR). FVA for the wild-type strain (E)-(H). Pink zones represent the maximal boundedness of the optimal solution space to support 95%-100% of maximal biomass production rates. Negative values indicate the reverse direction of the exchange reaction.