StressME: Unified computing framework of Escherichia coli metabolism, gene expression, and stress responses
Fig 2
Investigating sensitivity of predicted phenotypes and proteome to the kinetome (keff, effective rate constants).
(A) and (B): Distribution of Keffs for metabolic reactions used in previous single-stress ME models; (C) and (D): Effect of Keffs on growth rates simulated by StressME under different stress conditions; (E) and (F) Effect of Keffs on simulated protein mass fractions by StressME under different stress conditions.