A genome-wide comprehensive analysis of nucleosome positioning in yeast
Fig 5
The fPCs, their gene specific scores, and the discriminating boundary explain changing collective phasing in isw2Δrsc8chd1Δ.
The two clusters are given in orange and blue. The figure shows the fPC scores ζ of the isw2Δchd1Δrsc8 mutant and their separating boundary (black dashed line, A). The slope decreases with respect to the WT, making the gene groups almost solely dependent on the second fPC. Both fPCs transform the mean in a similar way as the double mutant rsc8chd1Δ (compare panel B with Fig 4E). The dashed black line as well as the solid lines in magenta and green indicate the mean, a positive contribution of the fPC, and a negative contribution, respectively. As expected, the separating boundary discriminate between the two clusters largely following the second fPC (C). The grey areas show the importance of each position to determine the clusters, whose median profile is shown as a blue and orange dashed line. The mean is depicted in black. All axes are scaled to the same size for each strain; shapes and amplitudes are therefore comparable.