Mutational signature dynamics indicate SARS-CoV-2’s evolutionary capacity is driven by host antiviral molecules
Fig 7
A. Signature exposures per month from wastewater sequences show similar trends in mutational processes as the global data, although at a lower resolution and, interestingly, with a lower Signature 2 exposure. B. Substitutions in SARS-CoV-2 consensus sequences from infections of immunocompromised individuals contain mutation types corresponding with patterns observed in the distinct signatures. Of note, there are more synonymous mutations present in the chronic infection data than in the global sequences, although it is important to note the sample size for immunocompromised infections is low. C. Mutation counts in wastewater sequences for bi-yearly time periods. Highly mutated sequences cluster to the right especially during the 2021 July-December time period, as would be expected when Omicron was emerging.