Mutational signature dynamics indicate SARS-CoV-2’s evolutionary capacity is driven by host antiviral molecules
Fig 6
A. Exposures for each of the SARS-CoV-2 mutational signatures for both synonymous and non-synonymous stratified datasets. Synonymous exposures are below 0 on the y-axis, while non-synonymous exposures are above 0. Each area represents signature exposures across epidemic weeks, with colours representing which signature the exposures are attributed to. B. Non-synonymous and synonymous mutations in the tree-based references of identified variants of concern. Signature 1 produces the majority of both synonymous and non-synonymous substitutions in all lineages. Signature 3 mutations are more often non-synonymous substitutions in the lineages of concern, with most lineages having few to no changes. Signature 2 non-synonymous mutations appear to have increased in the Omicron lineages (BA.1 and BA.2). C. Variant of concern associated non-synonymous mutations coloured by the mutational signature with the greatest likelihood of causing the change. D. Variant of concern synonymous mutations coloured by the putative mutational process that caused the change.