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Tying the knot: Unraveling the intricacies of the coronavirus frameshift pseudoknot

Fig 9

SARS-CoV-2 pseudoknot predictions overlap, 222 nt window via Shapify.

Top arc diagram: MFE-5, free energy −45.04 kcal/mol, initial stem 15 in black (free energy −2.74 kcal/mol). Note that the MFE-5 pseudoknot was also detected within the 144 nt window (see MFE-19) and the 68 nt window [25]. Bottom arc diagram: MFE-29, free energy −39.34 kcal/mol, initial stem 12 in black (free energy −3.41 kcal/mol). Attenuator hairpin sequence in fuchsia, slippery sequence in green, downstream native pseudoknot pairing region in red.

Fig 9

doi: https://doi.org/10.1371/journal.pcbi.1011787.g009