Index analysis: An approach to understand signal transduction with application to the EGFR signalling pathway
Fig 10
A: concentration-time profiles of Phosphatase3 and relevant cytosolic ERK species during signal activation. B: comparison of the output ERK-PP for the reference simulation (solid lines) and a modified model (dashed lines) with no Phosphatase3. As a result, signal activation speeds up by roughly 1 min, in addition to lack of signal deactivation.