Index analysis: An approach to understand signal transduction with application to the EGFR signalling pathway
Fig 9
Schematic with state classification of the signal transduction network focussing on the Shc dependent pathway for membrane EGFR signalling (Panel A) and internalised EGFR signalling (Panel B).
The schematics include the 20 state variables with largest maximum input-response index (light blue, see Fig 8D), environmental state variables (purple), state variables in quasi-steady state (green) and further state variables (dark blue). States being part of the membrane-bound and internalised pathway are coloured orange in panel (B). The red boxes mark the input and output state variables; coloured dots as part of reaction arrows indicate intermediate complexes. A similar graphic for the Shc-independent pathway is Fig I in S6 Supplementary Material.