Index analysis: An approach to understand signal transduction with application to the EGFR signalling pathway
Fig 8
Normalised ir-indices over time and ordered maximal value.
A, B and C: Normalised ir-indices for the three phases (0–0.3 min, 0.3–3 min, 3–100 min). Shown are all 20 indices with a maximal value exceeding δy = 10%. D: Order of decay of maximum value of the normalised ir-indices. All 20 states above the threshold of 10% are membrane-bound or free cytosolic forms and (as far as applicable) belong to the Shc-dependent pathway—as opposed to internalised forms and the Shc-independent pathway; see Table I in S6 Supplementary Material. The state just below the threshold is (EGF-EGFR*)2-GAP-Shc*-Grb2-Sos.