Index analysis: An approach to understand signal transduction with application to the EGFR signalling pathway
Fig 7
Output signal (left) and sum of ir-indices evolving over time (right).
A: Transient increase of ERK-PP (output) in response to the EGF (input) stimulus. Inset zoom: signal activation occurs within 3 min. B: Sum of ir-indices over time, showing three phases: initial peak (0–0.3 min), high plateau (0.3–3 min), and low plateau including decay (3–100 min).