Index analysis: An approach to understand signal transduction with application to the EGFR signalling pathway
Fig 2
Simple reaction cycle model and scenario-specific parameter values.
(A) Reaction network, and (B) parameter values for the three scenarios, for which the model system was studied. The time span was t ∈ [0, T] min with T = 0.01 or 0.1 (depending on the scenario), the input variable A, and the response variable D. The initial conditions were identical in all three scenarios: (A, B, C, D)0 = (0, 100, 5, 0) nM and input u0 = (2, 0, 0, 0) nM. Units: kon in 1/nM/min; all other reaction rate constants in 1/min.