Examining B-cell dynamics and responsiveness in different inflammatory milieus using an agent-based model
Fig 5
B-cell apoptosis, activation, and IL-10 during sepsis.
(A) Shows the total number of B-cells that undergo apoptosis. There is a significant increase in apoptosis after the septic antigen challenge on day 60. (B) Shows the average CD21 expression by naïve and memory B-cells. There is a significant decrease in CD21 expression, and therefore, level of activation, upon the septic antigen challenge. (C) Shows the total level of IL-10 secreted by regulatory B-cells. There is a large increase in the IL-10 levels following the septic exposure.