Examining B-cell dynamics and responsiveness in different inflammatory milieus using an agent-based model
Fig 3
B-cell apoptosis, activation, and IL-10 levels during mild antigen stimuli.
(A) Shows the total number of B-cells that undergo apoptosis. There is no appreciable level of apoptosis upon first or second exposures. (B) Shows the average CD21 expression by naïve and memory B-cells. There is no change in CD21 expression upon first or second exposures. (C) Shows the total level of IL-10 secreted by regulatory B-cells. There is a slight increase in the IL-10 levels following second exposure compared to the first exposure, corresponding to the increased regulatory B-cell differentiation.