Examining B-cell dynamics and responsiveness in different inflammatory milieus using an agent-based model
Fig 2
B-cell responses to mild antigen stimuli.
(A) Demonstrates the SLPC response. (B) Demonstrates the LLPC response. (C) Demonstrates the memory B-cell response. (D) Demonstrates the regulatory B-cell response. All four B-cell subtypes show a larger response upon second antigen exposure (day 60) compared to the first exposure (day 10). (B, C) The cells produced after the first and second exposure were color-coded black and red, respectively, in order to distinguish the magnitude of response for each exposure. This is necessary since the LLPCs and memory B-cells produced after the first exposure persist well into the second exposure. (A, D) The majority, if not all, of the cells produced after the first exposure die prior to the second exposure.