Systems approach for congruence and selection of cancer models towards precision medicine
Fig 2
UMAP for comparison of multiple data harmonization approaches.
UMAP for normalized BC tumors (n = 960) and BC cell lines (n = 65) to compare five normalization approaches: (A) no correction and (B) quantile normalization (C) ComBat and (D) Celligner utilizing BC tumors and BC cell lines (E) Celligner utilizing pan-cancer tumors and pan-cancer cell lines. The final approach best eliminates batch effects by mixing well the BC tumors and BC cell lines.