Novel metrics reveal new structure and unappreciated heterogeneity in Caenorhabditis elegans development
Fig 4
The union branch distance reveals Heterogeneity in RNAi Cell Cycle Timing Coordination.
(A) Heatmap showing the union branch distance between all 30 WT embryos and 1322 RNAi Embryos in the dataset. Embryos were hierarchically clustered and sorted into 4 clusters shown along the axes of the heatmap, with WT embryos visible as a “white block” in cluster 3. (B) i. Distribution of the tree edit distance between 6 SUF-1 embryos and 30 WT embryos. ii. Distribution of the intersection branch distance between 6 SUF-1 embryos and 30 WT embryos. iii. Distribution of the tree edit distance between 10 SKR-2 embryos and 30 WT embryos. iv. Distribution of the intersection branch distance between 10 SKR-2 embryos and 30 WT embryos. (C) Comparison between the tree edit distance and intersection branch distance for each of the 1322 RNAi embryos relative to a single WT reference embryo.