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Novel metrics reveal new structure and unappreciated heterogeneity in Caenorhabditis elegans development

Fig 3

The Branch Distance Reveals previously undetected Batch Effects in WT Embryo Cell Cycle Timing.

(A) Heatmap showing the union branch distance calculated between each pair of wild type embryos in the dataset. The ordering of embryos was sorted based on their assignment to two clusters computed using hierarchical clustering. (B) Heatmap showing the R2 in cell cycle times between all pairs of WT embryos, sorted as in (A). (C) The slope calculated between cell cycle times between all pairs of WT embryos, sorted as in (A).

Fig 3

doi: https://doi.org/10.1371/journal.pcbi.1011733.g003