Novel metrics reveal new structure and unappreciated heterogeneity in Caenorhabditis elegans development
Fig 2
Summation of Cycle Times into Birth Times Suppresses Variation.
(A) A comparison between the birth time of each cell (calculated as the sum of cell cycle times of each cell’s ancestors) in two wild type C. elegans embryos. (B) Comparison between birth times calculated from two randomly shuffled wild type embryos, where each cell is assigned another random cell’s birth time from within the lineage of the same embryo. Note that a significant correlation in birth times exists even in this shuffled data. (C) Comparison between shuffled cell cycle times rather than birth times. In this case, there is no correlation, as would be expected. (D) Comparison between the cell cycle times of each cell in two wild type embryos. Note that the same two embryos were used for all comparisons in panels A-D.