The role of cryptic ancestral symmetry in histone folding mechanisms across Eukarya and Archaea
Fig 5
Predicted structures of eukaryotic histone homodimer.
(A) AWSEM and AlphaFold2 predicted homodimer structures of H2A/H2A align well with the native heterodimer structure of H2A/H2B (colored in blue, orange, and green). (B) RMSF analysis of all-atom simulations demonstrates comparable stabilities of AWSEM- and AlphaFold2-predicted homo-complex structures (in blue and orange). RMSF of two chains are plotted separately and helix regions are animated by cartoon in grey.