Diffusive mediator feedbacks control the health-to-disease transition of skin inflammation
Fig 5
Dynamical characters underlying the five expanding and fading pattern types.
The phase space of pro- and anti-inflammatory mediator concentrations (a, i) depicts the time course (green curve) upon stimulation and the nullclines (red curve for da/dt = 0 in Eq 2A; blue curve for di/dt = 0 in Eq 2B; Da = Di = 0). The intersections of the nullclines indicate steady states, where filled and hollow circles represent stable and unstable states, respectively. The time course shows convergence to a stable steady state upon a supra-threshold stimulation at the initial condition (a = 1.0, i =0.01). Vector fields are also shown to represent mediator dynamics at the respective concentration. The parameter values for each simulation are listed in S2 Table.