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A cell-and-plasma numerical model reveals hemodynamic stress and flow adaptation in zebrafish microvessels after morphological alteration

Fig 8

Comparison of pressure and WSS distributions in ISVs amongst WT and Marcksl1 network models.

(A) Group-average (5 aISVs) of the time-averaged pressure drop (Pdrop_v) in aISVs amongst models (i) and the corresponding impedance (Rnet) (ii), blood flow rate (iii) and RBC flow rate (iv) in the aISVs. (B) Group-average (5 vISVs) of the time-averaged pressure drop (Pdrop_v) in vISVs amongst models (i) and the corresponding Rnet (ii), blood flow rate (iii) and RBC flow rate (iv) in the vISVs. (C) Group-averaged (5 aISVs) systolic peak WSS (WSSv_avg) in aISVs amongst models. (D) Group-averaged WSSv_avg in vISVs amongst models. Statistical comparisons were performed using one-way ANOVA with Sidak’s multiple pair comparisons. *, p < 0.05; **, p < 0.01; ****, p < 0.0001.

Fig 8

doi: https://doi.org/10.1371/journal.pcbi.1011665.g008