External mechanical loading overrules cell-cell mechanical communication in sprouting angiogenesis during early bone regeneration
Fig 8
Predicted vessel and cell organization after unloading the cortices with the baseline model vs. upon stromal cell traction forces inhibition.
(A) Distribution of the absolute maximum principal strains for the unloaded baseline model with a zoom into the gap; (B) Directions of the absolute maximum principal strains for the unloaded baseline model with a zoom into the gap; (C) Predicted vessel distribution for the unloaded baseline model (on the left) and for the unloaded OVSC_TF_KO model (on the right) and zoomed vessel organization in ROI 1; (D) vessel orientation analysis for the unloaded baseline and OVSC_TF_KO models within ROI1. Empty circles indicate a significant difference (p<0.05) between the baseline and OVSC_TF_KO model under unloading. Lines indicate a significant difference in the pairwise comparisons between angle bins in the same model (p<0.05); (E) Predicted OVSCs distribution for the unloaded baseline model and zoomed OVSCs organization within the gap; (F) percentage distribution of OVSCs orientations for the unloaded baseline model within the gap. OVSC_TF_KO = inhibition of OVSCs traction forces.