External mechanical loading overrules cell-cell mechanical communication in sprouting angiogenesis during early bone regeneration
Fig 6
Predicted vessel organization in the baseline model vs. upon endothelial cells mechano-response inhibition.
(A) Predicted vessel distribution for the baseline (left) and EC_MR_KO (right). The zoomed images of the osteotomy gap are reported below; (B) vessel orientation analysis for EC_MR_KO and baseline within the gap. Lines indicate a significant difference in the pairwise comparisons between angle bins in the EC_MR_KO model (p<0.05); (C) Box plots of vessel lengths for the baseline and EC_MR_KO within the whole healing region. The average vessel length is significantly different between the two groups (p<0.01); (D) The table shows the average number of self-intersecting vessels for the baseline and EC_MR_KO within the whole healing region. EC_MR_KO = inhibition of tip ECs mechano-response.